Distribution of serotonin 5-HT2C receptors in the ventral tegmental area
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چکیده
منابع مشابه
Evaluation of GABA Receptors of Ventral Tegmental Area in Cardiovascular Responses in Rat
Background: The ventral tegmental area (VTA) is well known for its role in cardiovascular control. It is demonstrated that about 20-30% of the VTA neurons are GABAergic though their role in cardiovascular control is not yet understood. This study is carried out to find the effects of GABA A and GABA B receptors on cardiovascular response of the VTA. Methods: Experiments were performed on uretha...
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The ventral tegmental area (VTA) is the origination zone for dopaminergic neurons involved in reward and addictive properties of a variety of abused substances. A major excitatory projection to VTA neurons originates in the medial prefrontal cortex, and several lines of evidence suggest that glutamatergic synapses on VTA neurons are activated and modified during exposure to psychostimulant drug...
متن کاملSerotonin 5-HT2C Receptors: Chemical Neuronatomy in the Mammalian Brain
Serotonin 5-HT 2C receptors belong to the 5-HT 2 family, which includes 5-HT 2A and 5-HT 2B receptors. All three share similarities in their molecular structure, pharmacology, and signal transduction pathways (Barnes and Sharp 1999; Hoyer et al. 1994). Initially named 5-HT 1C, based on the conventions for naming serotonin receptors at the time of its discovery, it was later renamed 5-HT 2C rece...
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Perfusion of the D1 agonist, SKF-82958, through a microdialysis probe implanted in the ventral tegmental area produced a dose-dependent increase in extracellular glutamate and GABA. The increase in extracellular glutamate occurred at approximately 30x lower dose than the elevation in GABA. The increase in extracellular glutamate by SKF-82958 was blocked by coperfusion of the D1 antagonist, SCH-...
متن کاملMorphine releases glutamate through AMPA receptors in the ventral tegmental area: a microdialysis study in conscious rats
Drug addiction has developed to a social illness. Changes in glutamate transmission have been recorded by the repeated administration of addictive drugs into VTA. In this investigation, In vivo microdialysis was used to study the effects of morphine on glutamate release from the ventral tegmentum area (VTA) in freely moving rats. Rats were anesthetized with chloral hydrate (350 mg/kg, i.p.) and...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2007
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2006.12.071